Effective Prolonged Therapy with Voriconazole in a Lung Transplant Recipient with Spondylodiscitis Induced by Scedosporium apiospermum

摘要

Scedosporium/Pseudallescheria species are frequently seen incystic fibrosis patients. However, disseminated forms after lungtransplantation in these patients are rarely seen, but often withpoor outcome. In this case report we describe a lung transplantrecipient with cystic fibrosis who developed a spondylodiscitisthat was caused by Scedosporium apiospermum. The patient wastreated with anti-fungal treatment by voriconazole for over threeyears with a clinical good response and without the need forsurgical intervention. To our opinion this is the firstanti-fungal treated case of invasive disease caused byScedosporium/Pseudallescheria in a cystic fibrosis (CF) patientwho underwent lung transplantation that survived.